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February 2011: ‘What is the future of HFA pMDIs? A patent-based perspective’

Date: February 1, 2011

This article discusses that over the last 20 years, inhalation drug delivery has been adjusting to the phase out of chlorofluorocarbon (CFC) propellants. Following the signature of the Montreal Protocol on September 16, 1987, there has been a rush to re-formulate pressure metered dose inhalers (pMDIs) using alternative propellant systems.

This paper also highlights that this has led to the advent of dry powder inhalers (DPIs), and to a prolific HFA (hydrofluoroalkane) pMDI patent field, resulting in a crowded patent landscape. The complexity of this landscape has led to myth and confusion with respect to the risks and opportunities in formulating HFA pMDIs.

This review aims to improve understanding of the intellectual property (IP) landscape. Understanding the past could help industry participants plan the future of pMDI inhalation delivery.

For more information on this article click here.

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